According to the "Notice on the Results of Handling Misconduct Cases Investigated and Prosecuted in 2022 (The Third Batch)" released by the National Natural Science Foundation of China on October 25, it involves many professors and doctors of Dalian Medical University's academic misconduct, many national natural The project was withdrawn, and multiple people were notified of criticism.

Recently, after investigation and deliberation by the Supervision Committee of the National Natural Science Foundation of China and approval by the executive meeting of the National Natural Science Foundation of China, the National Natural Science Foundation of China has dealt with the subjects involved in relevant scientific research misconduct cases. The relevant cases and handling results of the criticisms will now be notified:

(1) Announcement on the forgery and tampering of pictures in the papers published by Song Bo, Li Lianhong, Zhang Jun and Du Yue, and the results of false information processing in the project conclusion report

The Supervision Committee of the National Natural Science Foundation of China launched an investigation into 8 papers published by Song Bo, Li Lianhong, Zhang Jun, Du Yue, etc. of Dalian Medical University for suspected academic misconduct. The papers involved are as follows:

Paper 1: Lihui Yu#, Ying Lu#, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang, Bo Song*. microRNA- 140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5. Stem Cell Res. Ther., 2016, 7(1):180. (with reference to Fund No. 81172052)

Paper 2: Min Li#, Ying Lu#, Yunchao Xu, Jingwen Wang, Chenghong Zhang, Yue Du, Lu Wang, Lianhong Li, Bo Wang, Jie Shen, Jianwu Tang*, Bo Song*. Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis. Gene, 2018, 676:101-109. (with reference to grant number 81172052)

Paper 3: Jiazhi Li, Kun Zou, Lihui Yu, Wenyue Zhao, Ying Lu, Jun Mao, Bo Wang, Lu Wang, Shujun Fan, Bo Song*, Lianhong Li*. MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Mol. Ther. Nucleic. Acids, 2018, 10:426-437. (with fund numbers 81172052, 81272430)

Paper 4: Jun Zhang, Dan Liu, Zhuo Feng, Jun Mao, Chunying Zhang, Ying Lu, Jiazhi Li, Qingqing Zhang, Qing Li, Lianhong Li*. MicroRNA-138 modulates metastasis and EMT in breast cancer cells by targeting vimentin. Biomed . Pharmacother., 2016, 77:135-41. (marked with fund number 81272430)

Paper 5: Le Kang, Jun Mao, Yajun Tao, Bo Song, Wei Ma, Ying Lu, Lijing Zhao, Jiazhi Li, Baoxue Yang*, Lianhong Li*. MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci., 2015, 106(6):700-708. (marked with fund numbers 81272430, 81170632)

Paper 6: Yue Du#, Yuhong Huang#, Yue Gao, Bo Song, Jun Mao, Lina Chen, Lulu Bai, Jianwu Tang*. Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis. Biomed. Pharmacother., 2015, 74:30-34. (marked with fund numbers 81071725 and 30772468)

Paper 7: Bailong Li, Ying Lu, Honghai Wang, Xiaocui Han, Jun Mao, Jiazhi Li, Lihui Yu, Bo Wang, Shujun Fan, Xiaotang Yu, Bo Song*. miR-221/222 enhances the tumorigenicity of human breast cancer stem cells via modulation of PTEN/Akt pathway. Biomed. Pharmacother., 2016, 79:93-101. (with reference to Fund No. 81172052)

Thesis 8: Yunchao Xu#, Xu Liu#, Min Li, Yan Li, Chun-Yan Li, Ying Lu, Jaceline Sanches, Lu Wang, Yue Du, Li-Min Mao, Si-Bo Zuo, Hui-Ting Liu, Jie Shen, Bo Wang, Li Hou, Lian-Hong Li, Jian-Wu Tang, Jing-Fang Ju, Hong-Wei Guan*, Bo Song*. A Novel Mechanism of Doxorubicin Resistance and Tumorigenesis Mediated by MicroRNA-501-5p-Suppressed BLID. Mol. Ther. Nucleic. Acids, 2018, 12:578-590. (with reference to Fund No. 81172052)

After investigation, paper 1 has the problem of forging and tampering with pictures, and the corresponding author Song Bo and others are responsible for the above problems.

Paper 2 has the problem of forging and tampering with pictures, and the corresponding author Song Bo and others are responsible for the above problems.

Paper 3 has the problem of forging and tampering with pictures. Corresponding author Song Bo, co-corresponding author Li Lianhong and others are responsible for the above problems.

Paper 4 has the problem of forging and tampering with pictures. The first author Zhang Jun and the corresponding author Li Lianhong are responsible for the above problems. In addition, Li Lianhong included the paper in the final report of his National Natural Science Foundation of China (Grant No. 81272430), and is also responsible for the objective results of false information in the final report.

Paper 5 has the problem of forging and tampering with pictures. The first author Kangle and the corresponding author Li Lianhong are responsible for the above problems. In addition, Li Lianhong included the paper in the final report of his National Natural Science Foundation of China (Grant No. 81272430), and is also responsible for the objective results of false information in the final report.

Paper 6 has the problem of forging and tampering with pictures, and the first author Du Yue and others are responsible for the above problems.

Paper 7 has the problem of forging and tampering with pictures, and the corresponding author Song Bo and others are responsible for the above problems.

Paper 8 has the problem of forging and tampering with pictures, and the corresponding author Song Bo and others are responsible for the above problems.

After deliberation at the 14th meeting of the Fifth Supervision Committee of the National Natural Science Foundation of China and the 10th executive meeting of the National Natural Science Foundation of China in 2022, it was decided to follow the "Measures for Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China" forty Articles 7 and 40, cancel the Song Bo National Natural Science Foundation of China project "The role and mechanism of miR-140 in tumor metastasis" (Grant No. 81172052), recover the allocated funds, and cancel the Song Bo National Natural Science Foundation of China. Apply and participate in the application for 3 years (July 19, 2022 to July 18, 2025), and give Song Bo a notice of criticism.

Decided to revoke Li Lianhong's National Natural Science Foundation project "miR-34a in breast cancer stem cells self-renewal" Adjustment mechanism in the process (approval number 81272430)”, recover the allocated funds, cancel Li Lianhong’s National Natural Science Foundation project application and participation application qualification for 3 years (July 19, 2022 to July 18, 2025), give Li Lianhong Communicate criticism.

Decided to cancel Zhang Jun and Du Yue from the National Natural Science Foundation of China project application and participation application qualifications for 3 years (July 2022) From the 19th to July 18th, 2025), Zhang Jun and Du Yue were given a circular of criticism.

According to the public information on the website of the School of Basic Medicine of Dalian Medical University, Song Bo, female, doctor, professor, master tutor, is currently working in the Department of Pathology and Forensic Medicine of Dalian Medical University.

According to the public information on the website of Dalian Medical University School of Basic Medicine, Li Lianhong, male, doctor of medicine, double doctoral supervisor of pathology and forensic medicine, second-level professor, recipient of special government allowances from the State Council, is currently the chairman of the Graduate Education Evaluation Committee of Dalian Medical University and an undergraduate student. Member of the Education Evaluation Committee and Chairman of the Biomedical Ethics Committee.

(2) Announcement on the results of handling problems such as forgery and tampering with pictures in the papers published by Kangle

The Supervision Committee of the National Natural Science Foundation of China reviewed the papers "Le Kang, Jun Mao, Yajun Tao, Bo Song, Wei Ma, Ying Lu, Lijing Zhao, Jiazhi Li, Baoxue Yang*, Lianhong Li*. MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. Cancer Sci, 2015;106(6):700-8 ” (marked with fund numbers 81272430, 81170632) and launched an investigation for suspected academic misconduct.

After investigation, the paper has the problem of forging and tampering with pictures, and the first author Kangle, the corresponding author Li Lianhong and others should be responsible for the above problems.

After deliberation at the 14th meeting of the Fifth Supervision Committee of the National Natural Science Foundation of China and the 10th executive meeting of the National Natural Science Foundation of China in 2022, it was decided to follow the "Measures for Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China" forty Article 7 and Article 40, the qualification for Kangle National Natural Science Foundation project application and participation application will be cancelled for 3 years (July 19, 2022 to July 18, 2025), and Kangle will be notified of criticism.

For the decision on the handling of Li Lianhong, please refer to the National Science and Technology Financial Supervisory Office [2022] No. 115.

(3) Announcement on the forgery and tampering of pictures in the papers published by Shao Shujuan and Song Yang, and the results of false information processing in the project application and progress report

The Supervision Committee of the National Natural Science Foundation of China launched an investigation into two papers published by Shao Shujuan and Song Yang of Dalian Medical University for suspected academic misconduct. The papers involved are as follows:

Thesis 1: Yang Song#, Bing Sun#, Lihong Hao, Jun Hu, Sha Du, Xin Zhou, Liyuan Zhang, Lu Liu, Linlin Gong, Xinming Chi, Qiang Liu, Shujuan Shao*. Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma. Oncotarget, 2016, 7(36): 58470-58482.

Paper 2: Sha Du#, Zhuzhu Guan#, Lihong Hao, Yang Song, Lan Wang, Linlin Gong, Lu Liu, Xiaoyu Qi, Zhaoyuan Hou*, Shujuan Shao*. Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration. PLoS One, 2014;9(1):e85804. (marked with fund numbers 20935004, 81071784, 81172028)

After investigation, paper 1 has the problem of forging and tampering with pictures. The first author Song Yang, the corresponding author Shao Shujuan and others are responsible for the above issues. In addition, Shao Shujuan included Paper 1 in his application for the National Natural Science Foundation of China (Approval No. 81773122), and Song Yang included Paper 1 in his application for the National Natural Science Foundation of China (Application No. 3174100866, 8180101754, 8190111482). Both of them are responsible for the objective results of false information in the project application.

Paper 2 has the problem of forging and tampering with pictures. Corresponding author Shao Shujuan and others are responsible for the above issues. In addition, Shao Shujuan included Paper 2 in the application for the National Natural Science Foundation of China (Grant No. 81773122, 81470367) and the progress report of the National Natural Science Foundation of China (Grant No. 81272225). Responsible for the objective results of false information.

After deliberation at the 14th meeting of the Fifth Supervision Committee of the National Natural Science Foundation of China and the 10th executive meeting of the National Natural Science Foundation of China in 2022, it was decided to follow the "Measures for Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China" forty Article 7, Article 46, Article 40, the Shao Shujuan National Natural Science Foundation of China project "The role and mechanism of long-chain non-coding RNA-AS1 in lung cancer EMT (Grant No. 81773122) and "phosphoproteome" "Strategic Study on the Role of MCM2 Phosphorylation in Tumor Metastasis" (Grant No. 81470367), recovering the allocated funds, disqualifying Shao Shujuan from the National Natural Science Foundation of China for 3 years (July 19, 2022 to July 2025) March 18), and gave Shao Shujuan a notice of criticism.

Decided to revoke the Songyang National Natural Science Foundation project "The function of EMT-related long-chain non-coding RNA TBDR42 in lung cancer in accordance with Articles 47 and 40 of the "Measures for Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China" "Research on the function and mechanism of EMT-related long non-coding RNA TBDR42 in the invasion and metastasis of lung cancer" (Application No. 3174100866), "The role of NgBR in TGF-β1-induced non-small cell lung cancer" (Application No. 8180101754) The role and molecular mechanism in invasion and metastasis” (application number 8190111482), the Songyang National Natural Science Foundation of China project application and participation application qualification for 3 years (July 19, 2022 to July 18, 2025), granted to Songyang Yang Bulletin criticized.

According to public information, Shao Shujuan is a professor of human anatomy and tissue embryology at the School of Basic Medicine of Dalian Medical University, and a doctoral tutor.

According to the public information on the website of the School of Basic Medicine of Dalian Medical University, Song Yang, Ph.D., mainly focuses on the screening of lung cancer diagnostic protein markers and metastatic protein markers.

(4) Notification on the forgery and tampering of pictures in the papers published by Wang Shujing and the results of false information processing in the project final report

The Supervision Committee of the National Natural Science Foundation of China launched an investigation into two papers published by Wang Shujing and others of Dalian Medical University for suspected academic misconduct. The papers involved are as follows:

Paper 1: Yang Han, Lin Zhang, Xiao Yu, Shidan Wang, Chunyan Xu, Heng Yin*, Shujing Wang*. Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway. Cell Death Dis., 2019, 10(5):374. (marked with fund number 31470799)

Thesis 2: Y Zhao, A Wei, H Zhang, X Chen, L Wang, H Zhang, X Yu, Q Yuan, J Zhang*, S Wang*. α2,6-Sialylation mediates hepatocellular carcinoma growth in vitro and in vivo by targeting the Wnt/β-catenin pathway. Oncogenesis, 2017, 6(5):e343. (with reference to Fund No. 31470799)

After investigation, paper 1 has the problem of forging and tampering with pictures, and the corresponding author Wang Shujing and others are responsible for the above problems.

Paper 2 has the problem of forging and tampering with pictures, and the corresponding author Wang Shujing and others are responsible for the above problems. In addition, Wang Shujing included the involved paper in the final report of the National Natural Science Foundation of China (Grant No. 31470799), and is also responsible for the objective results of false information in the final report.

After deliberation at the 14th meeting of the Fifth Supervision Committee of the National Natural Science Foundation of China and the 10th executive meeting of the National Natural Science Foundation of China in 2022, it was decided to follow the "Measures for Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China" forty Article 7, Article 46, Article 40, the Wang Shujing National Natural Science Foundation of China project "Research on the role and mechanism of ST6Gal-I-mediated cell surface N-glycan sialylation in the occurrence and development of liver cancer and immune escape" ( Approval No. 31470799), recover the allocated funds, cancel Wang Shujing's National Natural Science Foundation of China project application and participation qualification for 3 years (July 19, 2022 to July 18, 2025), and give Wang Shujing a notice of criticism.

According to public information, Wang Shujing, female, born in 1982, Ph.D., professor, doctoral supervisor. He is currently a teacher in the Department of Biochemistry and Molecular Biology, School of Basic Medicine, Dalian Medical University, mainly engaged in research on tumor glycobiology and tumor immunology.

(5) Announcement on the use of pictures in the papers published by Peng Jinyong and the results of false information processing in the project application

The National Natural Science Foundation of China Supervision Committee reviewed the paper "Xufeng Tao, Lina Xu, Lianhong Yin, Xu Han, Yan Qi, Youwei Xu, Shasha Song, Yanyan Zhao, Jinyong Peng*. Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β. Cell Death Dis. 2017, 8(8): e2989.” was investigated for alleged academic misconduct.

After investigation, it was found that there was a problem of confusion in the use of pictures in this paper, and the corresponding author Peng Jinyong and others should be responsible for the above problems. In addition, Peng Jinyong listed the papers involved in his application for the National Natural Science Foundation of China (Approval No. 81872921), and is also responsible for the objective results of false information in the project application.

After deliberation at the 14th meeting of the Fifth Supervision Committee of the National Natural Science Foundation of China and the 10th executive meeting of the National Natural Science Foundation of China in 2022, it was decided to refer to the 40th "Measures for the Investigation and Handling of Scientific Research Misconduct of National Natural Science Foundation of China Projects" Article, Peng Jinyong National Natural Science Foundation of China project "MiR-23a-5p targeting HSP20 and PPARα regulates the molecular mechanism of intestinal ischemia-reperfusion injury and the intervention of diosgenin" (Grant No. 81872921), and the allocated funds are recovered. Peng Jinyong's National Natural Science Foundation of China project application and participation qualifications will be cancelled for 2 years (July 19, 2022 to July 18, 2024), and Peng Jinyong will be criticized.

According to public information, Peng Jinyong, male, born in October 1973, doctor of pharmacy, postdoctoral fellow in analytical chemistry, is now a professor at the School of Pharmacy, Dalian Medical University.